About RWE

Understanding RWE

Randomized Controlled Trials (RCTs) are the gold standard of drug assessment, as they assess the efficacy and safety results for a new therapeutic option. However, the patient populations that are treated in everyday practice may be somewhat different from those studied in RCTs due to the strict inclusion and exclusion criteria of RCTs. Thus, RWE helps provide important additional information about the effectiveness and safety profile of new therapies in wider patient populations. This section provides a background on what RWE is and why it can be important to consider in clinical decision making.

Why RWE matters

Real-world evidence and why it is important to clinical decision making
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Efficacy vs. effectiveness

Factors impacting the feasibility and effectiveness of treatment in the real world
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Strengths and limitations

Reviewing data sources for real‑world evidence
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